The Servant Girl Annihilator, aka the Austin Axe Murderer and the Midnight Assassin, was an unidentified serial killer who preyed upon the city of Austin between 1884 and 1885. The murders represent an early example of a serial killer operating in the United States, three years before the Jack the Ripper murders in London. The conjecture that the Texas killer and Jack the Ripper were one and the same originated in October 1888, when an editor proposed this following the murders of Elizabeth Stride and Catherine Eddowes.

On December 6, 1991, a quadruple homicide took place at an I Can't Believe It's Yogurt in Austin, TX. The victims were four teenage girls: Amy Ayers, Eliza Thomas, Jennifer Harbison, and Sarah Harbison. The case remains unsolved.

Megan Romero Curl was just 26 years old when she was found tied to her bed post and set on fire. Her charred remains showed her throat had been slashed to bone and a plastic bag placed over her head. Her killer has gone unidentified since March 26, 2000.